Dr. Manoj Baranwal

Professor

Specialization

Viral Immunology, Computational Biology

Email

manoj.baranwal@thapar.edu; Date of Joining: 31-05-2009

Specialization

Viral Immunology, Computational Biology

Email

manoj.baranwal@thapar.edu; Date of Joining: 31-05-2009

Linkedin 

Google Scholar

Website Link

Educational Qualification

  1. Ph.D (Immunology): University of Duisburg-Essen, Germany (2007)
  2. PG Diploma (Bioinformatics): Bioinformatics Centre, Jawaharlal Nehru University (JNU), New Delhi (2003)
  3. M.Sc (Life Sciences): School of Life Sciences, JNU, New Delhi (2002)
  4. B.Sc (Chemisty): Gaya College, Magadh University, Gaya (2000)

Professional Experience

  1. Professor, Dept of Biotechnology, Thapar Institute of engineering and Technology (TIET), Patiala (1st July 2022 to till date)

  2. Associate Professor, Dept of Biotechnology, Thapar Institute of engineering and Technology, Patiala (10th July 2017 to 30th June 2022)
  3. Assistant Professor: Dept of Biotechnology, Thapar Institute of Engineering & Technology, Patiala (July 2009-July 2017)
  4. Assistant Professor: Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Pune (March 2008-July 2009)
  5. Postdoctoral Research Fellow: Institute of Immunology, University Hospital, Essen, Germany (March 2007 to January 2008)

Research Interest 

  • Immunoinformatics and cellular immunology with prime focus in peptide based vaccine design against viral disease
  • Anticancer & immunomodulatory study of natural products and nanoparticles.
  • Development of disease predictive model with application of machine learning and artificial intelligence.

Research Projects

  • Identification of immunogenic peptide for diagnosis of orthohantavirus infection: under Indo-Russian Joint Research Call  from DST, New Delhi (2022: Granted)

  • In silico and in vitro approach to identify immunogenic peptides of H1N1 virus as a target for vaccine design from DST, New Delhi, Sanction amount: 23.6 Lakhs (Jan 2013 to Jan 2016) (PI)
  • Identification of T cell Epitope in H1N1 influenza virus as target for vaccine design from AICTE, New Delhi, Sanction amount: 11 lakhs (March 2012 to March 2014) (PI)
  • Immunomodulatory agents from endophytic fungi for breast cancer therapy from DBT, New Delhi, Sanction amount: 16.02 lakhs (Nov 2011 to October 2014) (PI)

As Co-Project Investigator

  • Analysis of virus transport through subsurface media from CSIR, New Delhi, Sanction amount: 23.42 lakhs (Dec 2017 to Nov 2020)

Publication of Research Articles: 50+

2021 onwards

  • Kaushal, N., Jain, S., Baranwal, M (2022) Computational design of immunogenic peptide constructs comprising multiple human leukocyte antigen restricted dengue virus envelope epitopes. Journal of Molecular Recognition
  • Chalotra, A., Ratha, D., Babbar, R., Baranwal M (2022) A study on transport of Escherichia coli through saturated porous medium. International Journal of Environmental Science and Technology
  • Singh, S., Singh, N., Baranwal, M., Sharma S (2022) Polymorphisms in the MSH2 gene predict poor survival of North Indian lung cancer patients undergoing chemotherapy. Journal of Cancer Research and Therapeutics
  • Martynova, E., Hamza, S., Markelova, M., Garanina, E., Davidyuk ,Y., Shakirova, V., Kaushal, N., Baranwal, M., Stott-Marshall, R., Foster, T., Rizvanov, A., Khaiboullina S. (2022) Immunogenic SARS-CoV-2 S and N protein peptide and cytokine combinations as biomarkers for early prediction of fatal COVID-19. Frontiers in Immunology 13, 830715
  • Garanina, E., Martynova, E., Hamza, S., Marshall, RS., Markelova, M., Davidyuk, Y., Shakirova, V., Kaushal, N., Baranwal, M., IKhaertynova, I., Rizvanov, A., Foster, T., Khaiboullina S (2022) Antibody and T Cell Immune Responses to SARS-CoV-2 Peptides in COVID-19 Convalescent Patients. Frontiers in microbiology, 13, 842232
  • Singh, S., Singh, N., Baranwal, M. and Sharma, S. (2022) Polymorphisms in the MSH2 gene predict poor survival of North Indian lung cancer patients undergoing chemotherapy. Biomarkers in Medicine

  • Patwal, T., & Baranwal, M. (2021). Scenedesmus acutus extracellular polysaccharides produced under increased concentration of sulphur and phosphorus exhibited enhanced proliferation of peripheral blood mononuclear cells. 3 Biotech, 11(4), 171. 

  • Sharma, P., Goyal, D., Baranwal, M., & Chudasama, B. (2021). Oxidative Stress Induced Cytotoxicity of Colloidal Copper Nanoparticles on RAW 264.7 Macrophage Cell Line. Journal of Nanoscience and Nanotechnology, 21(10), 5066–5074.

  • Johri, S., Goyal, M., Jain, S., Baranwal, M., Kumar, V., & Upadhyay, R. (2021). A novel machine learning‐based analytical framework for automatic detection of COVID ‐19 using chest X‐ray images. International Journal of Imaging Systems and Technology, ima.22613

  • Martynova, E., Davidyuk, Y., Kabwe, E., Garanina, E. E., Shakirova, V., Pavelkina, V., Uskova, Y., Stott, R. J., Foster, T. L., Markelova, M., Goyal, M., Gupta, A., Bhola, M., Kumar, V., Baranwal, M., Rizvanov, A. A., & Khaiboullina, S. F. (2021). Cytokine, chemokine, and metalloprotease activation in the serum of patients with nephropathia epidemica from the republic of tatarstan and the republic of mordovia, Russia. Pathogens, 10(5), 527

2018-20

  • Martynova, E., Goyal, M., Johri, S., Kumar, V., Khaibullin, T., Rizvanov, A. A., Verma, S., Khaiboullina, S. F., & Baranwal, M. (2020). Serum and cerebrospinal fluid cytokine biomarkers for diagnosis of multiple sclerosis. Mediators of Inflammation, 2020.

  • Jain, Sahil, Khaiboullina, S. F., & Baranwal, M. (2020). Immunological perspective for ebola virus infection and various treatment measures taken to fight the disease. Pathogens, 9(10), 850.

  • Kaushal, N., Gupta, Y., Goyal, M., Khaiboullina, S. F., Baranwal, M., & Verma, S. C. (2020). Mutational frequencies of SARS-CoV-2 genome during the beginning months of the outbreak in USA. Pathogens, 9(7), 1–16. .

  • Sharma, P., Goyal, D., Baranwal, M., & Chudasama, B. (2020). ROS-induced cytotoxicity of colloidal copper nanoparticles in MCF-7 human breast cancer cell line: an in vitro study. Journal of Nanoparticle Research, 22(8), 244.

  • Goyal, M., Khanna, D., Rana, P. S., Khaibullin, T., Martynova, E., Rizvanov, A. A., Khaiboullina, S. F., & Baranwal, M. (2019). Computational intelligence technique for prediction of multiple sclerosis based on serum cytokines. Frontiers in Neurology, 10, 781 (2019)

  • Goyal, M., Baranwal, M., Pandey, S. K., & Reddy, M. S. (2019). Hetero-Polysaccharides Secreted from Dunaliella salina Exhibit Immunomodulatory Activity Against Peripheral Blood Mononuclear Cells and RAW 264.7 Macrophages. Indian Journal of Microbiology, 59 (4), 428-435 .

  • Jain, S., & Baranwal, M. (2019). Conserved peptide vaccine candidates containing multiple Ebola nucleoprotein epitopes display interactions with diverse HLA molecules. Medical Microbiology and Immunology,208: 227-238

  • Jain, S., & Baranwal, M. (2019). Computational analysis in designing T cell epitopes enriched peptides of Ebola glycoprotein exhibiting strong binding interaction with HLA molecules. Journal of Theoretical Biology, 465, 34-44

  • Dhiman, G., Srivastava, N., Goyal, M., Rakha, E., Lothion-Roy, J., Mongan, N. P., Miftakhova, R. R., Khaiboullina, S. F., Rizvanov, A. A., & Baranwal, M. (2019). Metadherin: A therapeutic target in multiple cancers. Frontiers in Oncology 9, 349

  • Goyal, M., Kaur H., Bhandari M., Rizvanov, A. A., Khaiboullina, S. F., & Baranwal, M. (2018) Antioxidant and Immune Effects of Water Soluble Polysaccharides Isolated from Cinnamomum verum Bark. BioNanoScience, 8(3), 935-940

  • Khaiboullina S., Uppal T., Martynova E., Rizvanov A., Baranwal, M. & Verma S. C. (2018) History of ZIKV infections in India and management of disease outbreaks. Frontiers in Microbiology, 9, 2126 

  • Lohia N., & Baranwal, M. (2018) Highly conserved hemagglutinin peptides of the H1N1 influenza virus elicit immune response. 3 Biotech, 8(12), 492

2014-17

  • Lohia, N., & Baranwal, M. (2017). Immune responses to highly conserved influenza A virus matrix 1 peptides. Microbiology and Immunology, 61(6), 225-231.

  • Sharma, V., Lohia, N., Handa, V., & Baranwal, M. (2017). Amomum subulatum seed extract exhibit antioxidant, cytotoxic and immune-suppressive effect. Indian Journal of Biochemistry and Biophysics, 54(3–4)..

  • Vasundhara, M., Baranwal, M., Sivaramaiah, N., & Kumar, A. (2017). Isolation and characterization of trichalasin-producing endophytic fungus from Taxus baccata. Annals of Microbiology, 67(3), 255-261.

  • Dhiman, G., Lohia, N., Jain, S., & Baranwal, M. (2016). Metadherin peptides containing CD4+and CD8+T cell epitopes as a therapeutic vaccine candidate against cancer. Microbiology and Immunology, 60(9), 646-652.

  • Singh, P., Baranwal, M., & Reddy, S. M. (2016). Antioxidant and cytotoxic activity of carotenes produced by Dunaliella salina under stress. Pharmaceutical Biology, 54(10) 2269-2275.

  • Vasundhara, M., Baranwal, M., & Kumar, A. (2016). Fusarium tricinctum, An Endophytic Fungus Exhibits Cell Growth Inhibition and Antioxidant Activity. Indian Journal of Microbiology,  56(4), 433-438.

  • Lohia, N., & Baranwal, M. (2015). Identification of conserved peptides comprising multiple T Cell epitopes of matrix 1 protein in H1N1 influenza virus. Viral Immunology, 28(10), 570-579 (2015).

  • Lohia, N., & Baranwal, M. (2014). Conserved peptides containing overlapping CD4+ and CD8+ T-cell epitopes in the H1N1 influenza virus: An immunoinformatics approach. Viral Immunology, 27(5), 225-234.​

Before 2014

  • Putzki, N., Baranwal, M. K., Tettenborn, B., Limmroth, V., & Kreuzfelder, E. (2010). Effects of natalizumab on circulating B cells, T regulatory cells and natural killer cells. European Neurology,63(5), 311-317 (2010).

  • Putzki, N., Kumar, M., Kreuzfelder, E., Grosse-Wilde, H., Diener, H. C., & Limmroth, V. (2008). Mitoxantrone does not restore the impaired suppressive function of natural regulatory t cells in patients suffering from multiple sclerosis. European Neurology, 61(1) 27-32.

  • Yaldizli, O., Kumar, M., Vago, S., Kreuzfelder, E., Limmroth, V., & Putzki, N. (2009). Fatigue is not associated with impaired function of regulatory T cells in untreated patients with multiple sclerosis. European Neurology, 62(6), 321.

  • Kumar, M., Putzki, N., Limmroth, V., Remus, R., Lindemann, M., Knop, D., Mueller, N., Hardt, C., Kreuzfelder, E., & Grosse-Wilde, H. (2006). CD4+CD25+FoxP3+T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis. Journal of Neuroimmunology, 180(1), 178-184.

Chapters

  • Lohia, N., & Baranwal, M. (2020) An Immunoinformatics Approach in Design of Synthetic Peptide Vaccine Against Influenza Virus. In Immunoinformatics.  Humana, New York, NY, 229-243.

  • Tania, Goyal M., & Baranwal, M. (2018) In Silico Approach to Analyze the Biochemical Pathways of Bacterial Metabolite Synthesis. In:  In Silico Approach for Sustainable Agriculture. Springer, 141-159 

Research Guidance

  • PhD: Completed (3) and Ongoing (6)
  • M.Sc/M.Tech: Completed (36)

Research Collaboration: Kazan Federal University, Russia

Membership of national/International organization

  1. Life Member of Indian Immunological society
  2. Life Member of Mycology society of India
  3. Member of German Society of Immunology from 2005-2007

Courses Taught:

Immunology, Cancer biology and infectious disease, Applied Immunology & Vaccine Technology, Advanced Bioinformatics, Bioinformatics & System Biology, Virology, Animal Biotechnology, Stem Cells, Bioethics, Environmental studies.

Programme Organized

  • 1. National conference on Emerging Trends in Biopharmaceuticals: Relevance to Human Health during, held at Thapar University, Patiala, Punjab (November 11-13th, 2010) as Organizer Secretary.
  • 2. International conference on Drug Discovery: Biotech and Pharma at CrossRoads, being organized by the Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala (15-17th Feb 2018) as Treasurer.

Academic Activity

Current Activity

•National Board of Accreditation: Department overall coordinator

•Member secretary of Institutional ethical committee

•Time Table coordinator

Past Activity

•Department Faculty placement coordinator

•UG coordinator of B. Tech Biotechnology

•Industry associated project coordinator

•Deputy superintendent (End semester examination conduct)

•Member of several admission committee

 

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