Dr. Sanjai Saxena

Professor

Specialization

Plant-microbe/animal-microbe interaction, natural product based drug discovery

Email

ssaxena@thapar.edu

Specialization

Plant-microbe/animal-microbe interaction, natural product based drug discovery

Email

ssaxena@thapar.edu

Specialization

Plant-microbe/animal-microbe interaction, natural product-based drug discovery, biopreservatives, biopesticides.

Email

ssaxena@thapar.edu

Professional Identity:

LinkedIn

Academic Identities:

Google, Vidwan, Orcid, Scopus,

ACADEMIC PREPARATION

  1. Ph.D. Biological Sciences, spl. Fungal biotechnology Department of Biological Sciences, Rani Durgavati University (2000)
  2. M.Sc. Biological Sciences spl. Biotechnology, Department of Biological Sciences, Rani Durgavati University (1996)
  3. B.Sc. Hons. Botany, University of Delhi (1992)

PROFESSIONAL SYNOPSIS

Over 19 years of leadership in the interface of Biotechnology, agriculture and pharma. My research basically pertains to plant- microbe interactions occurring in the nature which are mediated through a variety of signal molecules playing a critical role in the communication. I am involved in harnessing these interactions as well as exploration of the novel biomolecules involved which can be effectively used in improving the agricultural productivity as well as in healthcare as medicines.  This is actually achieved by development of different screening platforms for biological activities which can be clearly demarcated as phytotoxic assays; physiological assays to see abiotic /biotic stresses in plant systems and anti-microbial, anti-oxidant, anti-cancer or finding novel molecules which interfere in the mechanism of development of diseases such as Alzheimer's Dementia (AD), Parkinson's disease (PD), Obesity, Anti-gout/arthritic and type II Diabetes

RESEARCH DOMAINS (Industrial/ Medicinal Biotech):

Drug Discovery; plant-microbe interaction; cellular biochemistry and cell biology; microbial biochemistry; clinical microbiology; enzymology; Food security and Ethnopharmacology.

RESEARCH ACCOMPLISHMENTS

  1. 03 PATENTS (01 US; 02 INDIAN);
  2. SPONSORED RESEARCH PROJECTS COMPLETED: 11.1 million INR (1.11 crore rupees) from Govt. agencies.
  3. DEVELOPED –STATE OF THE ART – ANIMAL TISSUE CULTURE FACILITY FOR RESEARCH & TEACHING in the year 2009-2010
  4. Leading an independent research group in the area of DRUG DISCOVERY, CHEMICAL BIOLOGY & NATURAL PRODUCTS
  5. Scientific contribution includes >60 peer reviewed international publications; 6 Book chapters; 01 book entitled “Applied Microbiology” by Springer India and several presentations in national as well as international conferences
  6. Research networking: Tel Aviv University, Israel; Pontifical Catholic University, Brazil; National Institute of Pharmaceutical Research and Education (NIPER), India; Cape Peninsula University of Technology, South Africa
  7. Intota Expert in providing consultancy in the area of Anti-microbial drugs and Clinical Microbiology (Expert 728374)
  8. Guided over 07 doctoral dissertations, 04 ongoing
  9. Guided 60 postgraduate dissertations

R&D SYSTEMS ADMINISTRATION

  1. SERVED AS COORDINATOR (HEAD) of CENTRE FOR RELEVANCE & EXCELLENCE (CORE) in AGRO & INDUSTRIAL BIOTECHNOLOGY, I have been involved in brandishing the center, expanding the research horizon as per the current industrial scenario, networking with industries like PEPSICO INDIA LTD; McCAIN; TECH MAHINDRA; BILTTREE TECH; looking into financials for it to be a self-sustaining entity; providing technical; infrastructural support to students, researchers (students as well as faculty) within the institute and in the region; submission of grant applications (bilateral/national/ multinational).
  2. WRITING AND SUBMISSION OF GRANTS –BILATERAL / MULTILATERAL
  3. As DEPUTY COORDINATOR, SCIENCE & TECHNOLOGY ENTREPRENUERS PARK (STEP) at Thapar Institute of Engineering & Technology, I have been instrumental in brand development for enhancing the concept of entrepreneurship in the area of Agro and Food Biotechnology apart from providing the support in day to day administration in operation of STEP.
  4. Member of Project review committee for competitive research grants in Department of Biotechnology (DBT), Ministry of Science and Technology, Govt. of India and SERB (Science & Engineering Research Board), Department of Science & Technology.
  5. Expert Member for Biotechnology & Life Sciences Research for S&T Roadmap of 10 (ten) life science laboratories of Defence Research & Development Organization (DRDO), Ministry of Defence, Govt. of India and for developing collaboration with academia.

RECENT PUBLICATIONS

2019

  • Geetika Gupta, Manoj Baranwal, Sanjai Saxena, and Mondem Sudhakara Reddy (2019): Utilization of Banana Stem Juice as a Feedstock Material for Bioethanol Production. Clean – Soil, Air, Water 47, 1900047

 

  • Vagish Dwibedi, S Kalia, Sanjai Saxena (2019): Isolation and enhancement of resveratrol production in Xylaria psidii by exploring the phenomenon of epigenetics: using DNA methyltransferases and histone deacetylase as epigenetic modifiers. Molecular Biology Reports 46, 123–4137

 

  • Vagish Dwibedi and Sanjai Saxena (2019): Diversity and phylogeny of resveratrol-producing culturable endophytic fungi from Vitis species in India. 3Biotech 9, 182. https://doi.org/10.1007/s13205-019-1712-x

 

  • D Singh, A Babbar, V Jain, D Gupta, S Saxena, V Dwibedi (2019): Synthesis, characterization, and bioactivity investigation of biomimetic biodegradable PLA scaffold fabricated by fused filament fabrication process. J Braz. Soc. Mech. Sci. Eng. 41, 121. https://doi.org/10.1007/s40430-019-1625-y

 

  • Neha Kapoor, Lokesh   Gambhir and Sanjai Saxena (2019): Fungal endophytes as repository of xanthine oxidase inhibitors. Indian Drugs 56(3), 07-11

 

  • Sanjay Kumar, Amol Dilip Pagar, Furkan Ahmad, Vagish Dwibedi, Aabid Wani, Prasad V. Bharatam,  Manmohan Chhibber, Sanjai Saxena , Inder Pal Singh (2019): Xanthine oxidase inhibitors from an endophytic fungus Lasiodiplodia pseudotheobromae. Bioorganic Chemistry, 87, 851-856. https://doi.org/10.1016/j.bioorg.2018.12. 008  

 

  • Lokesh Gambhir, Vineet Sharma, Pankaj Kandwal, Sanjai Saxena (2019): Perturbation in cellular redox homeostasis: Decisive regulator of T cell mediated immune responses. International Immunopharmacology 67, 449-457

 

  • Sanjai Saxena, Manmohan Chhibber and I. P. Singh (2019): Fungal bioactive compounds in Pharmaceutical Research and Development, Current Bioactive Compounds 15 (2), 211-231

 

2018

  • Neha Kapoor, Lokesh Gambhir and Sanjai Saxena (2018): Secondary structure prediction of ITS rRNA region and Molecular phylogeny: An integrated approach for precise speciation of Muscodor species.  Annals of Microbiology 68 (11), 763-772

 

  • Sunil Kumar Deshmukh, Manish K. Gupta, Ved Prakash and Sanjai Saxena (2018): Endophytic Fungi: A Source of Potential Antifungal Compounds. J. Fungi, 4(3), 77; https://doi.org/10.3390/jof4030077

 

  • Neha Kapoor and Sanjai Saxena (2018): Endophytic fungi of Tinospora cordifolia with anti-gout properties. 3Biotech 8: 264. https://doi.org/10.1007/s13205-018-1290-3

 

  • Vagish Dwibedi and Sanjai Saxena (2018): Arcopilus aureus, a resveratrol producing endophytic fungi from Vitis vinifera. Applied Biochemistry & Biotechnology 186(2), 476-495. https://doi.org/10.1007/s12010-018-2755-x

 

2017

  • Vineet Meshram, Sanjai Saxena, Karan Paul, Mahiti Gupta and Neha Kapoor (2017): Production, purification and characterization of a potential fibrinolytic protease from endophytic Xylaria curta by solid substrate fermentation. Applied Biochemistry & Biotechnology 181:1496–1512

 

  • Meshram V, Kapoor N, Chopra G and Saxena S (2017): Muscodor camphora, a new endophytic species from Cinnamomum camphora. Mycosphere 8(4): 568-582

 

  • Divya Singhal and Sanjai Saxena (2017): Catechin gallate a promising resistance modifying candidate to potentiate b-lactam antibiotics to overcome resistance in Staphylococcus aureus. Current Medicine Research and Practice 7: 224228

 

  • Renu Narain, Sanjai Saxena and Achal Kumar Goyal (2017): A Novel Heart Disease Prediction System Based on Quantum Neural Network Using Clinical Parameters. Annual Research & Review in Biology 14(2): 1-10

 

REVIEWER/ EXPERT FOR REPUTED JOURNALS

2003 Journal of Plant Physiology Indian Journal of Pharmacology Indian Journal of Experimental Biology

2004 Indian Journal of Pharmacology Letters in Applied Microbiology

2005 Indian Journal of Pharmacology

2006 Indian Journal of Pharmacology Journal of Applied Microbiology

2007 Journal of Applied Microbiology Letters in Applied Microbiology

2008 Journal of Ethnopharmacology Journal of Applied Microbiology

2009 Journal of Ethnopharmacology Journal of Applied Microbiology

2010 Biocontrol Science & Technology Letters in Applied Microbiology Journal of Ethnopharmacology

2011 Pharmaceutical Biology Journal of Ethnopharmacology Applied Microbiology & Biotechnology

2012 Journal of Ethnopharmacology

2013 Journal of Ethnopharmacology Letters in Applied Microbiology Pharmaceutical Biology

2014 Journal of Basic Microbiology Journal of Food Biochemistry Indian Journal of Microbiology

2015 Journal of Food Biochemistry Journal of Ethnopharmacology Journal of Basic Microbiology  Crop Protection Applied Microbiology & Biotechnology Indian Journal of Microbiology

2016 BMC Complimentary & Alternative Medicine Sydowia Canadian Journal of Microbiology

2017 Applied Microbiology & Biotechnology

2019 3Biotech MethodsX

2020 The British Medical Journal

AWARDS AND HONORS

2020

AGPHARM BIOINNOVATIONS LLP (startup promoted by Prof. Saxena), wins the Social Alpha Quest for Agritech Innovations becomes a part of the first cohort of the India Agritech Incubation Network (IAIN) jointly promoted by the Bill and Melinda Gates Foundation, Tata Trusts and SIIC, IIT Kanpur.

2018

DST- Lockheed Martin-Tata Trusts–FICCI-India Innovation Growth Program (IIGP) 2.0 University Challenge 2018 Award, for Rs. 10 Lakh under the Social Theme for Innovative product development to enhance shelf life of fruits and vegetables at the Farm end and Transportation, at Hotel Taj Mahal, Man Singh Road, New Delhi on August 02, 2018

2018

Challenge for Change- Innovation/Startup Award, for Rs. 25 lakhs for a solution to enhance the shelf life of agricultural produce by the Department of IT & Communications, Govt. of Rajasthan at Digifest held on 27th July 2018 at Bikaner.

2014

Eminent Microbiologist Award by Association for Advancement of Biodiversity Science, Dharwad, Karnataka, India

2013

FABS (Fellow of Association for Advancement of Biodiversity Science), Dharwad, Karnataka

2012

Bharat Jyoti Award, India International Friendship Society, New Delhi

2012

M.J Thirumalachar Merit award, for best poster presentation by Mycological Society of India (MSI), Chennai, India

2010

Biographed in Marquis Who’s Who World

2006

Biographed in Marquis Who’s Who Asia

2001

ICSU-INSA Travel Award, Indian National Science Academy (INSA), New Delhi, India

1999

Best Oral Presentation in Young Scientist Session at an International Conference of Plant–pathogen interactions, Osmania University, Hyderabad

1996-2000

Junior Research Fellow, Indian Council for Forestry Research & Education (ICFRE), Dehradun

1996

T. D. Dharmadhikari Gold Medal and Certificate of Merit for securing first class first position in M. Sc. Biological Science at Rani Durgavati University, Jabalpur

1996

Qualified GATE (Graduate Aptitude Test in Engineering) Life Sciences, MHRD, GoI

MEMBERSHIP OF PROFESSIONAL SOCIETIES

  • Life member, Association for Advancement of Biodiversity Science
  • Life member, International Society of Fungal Conservation
  • Life member, Society for Basic and Applied Mycology, India
  • Life member, Mycological Society of India (MSI), Chennai
  • Life member, Association for promotion of DNA fingerprinting and other related technologies (ADNAT), Hyderabad
  • Member, American Nano Society
  • Councillor, Mycological Society of India

EXPERT FOR OTHER ORGANIZATIONS

2018

Lead (Chair) Screening LoI’s under the 5th BioCARe Projects Call, DBT, Ministry of Science & Technology, GoI

2018

Expert Member in 4th review committee of BioCARe Projects, DBT, Ministry of Science & Technology, GoI

2017

Reviewer of Sponsored Projects, Department of Biotechnology (DBT), Ministry of Science & Technology, GoI

2016

Expert Member in review committee of BioCARe Projects, DBT, Ministry of Science & Technology, GoI

2014

Reviewer / Expert for SERB projects, DST, GoI

2013

Expert Reviewer for NER Twining projects (Aromatic & Medicinal Plants), DST, GoI

2008/9

Expert Member, Central Ayurvedic Pharmaceutical Testing Reference Laboratory, Patiala

2008/9

Expert Reviewer, International Collaborative Projects, DBT, GoI

2007

Expert, Biotechnology and Life Sciences Research for Science and Technology Roadmap of 10(ten) life sciences Laboratories of Defence Research and Development Organization (DRDO)

ACADEMIC EXPERT/ RESOURCE PERSON

2018         External Ph.D. examiner, North East Hill University (NEHU), Shillong, Meghalaya

2014         External M. Phil examiner, Lovely Professional University, Jalandhar, Punjab

2012         External M. Phil examiner, Lovely Professional University, Jalandhar, Punjab

2011         External examiner, Maharishi Markandeshwar University, Mullana, Haryana

          External examiner, Ambala College of Engineering, Mithapur, Ambala (Kurukshetra   University)

2009         External M. Phil examiner, Rani Durgavati University, Jabalpur (Madhya Pradesh)

2008         External Ph.D. Examiner, for Bharathiar University, Coimbatore (Tamil Nadu)

CONFERENCES & WORKSHOPS ORGANIZED

2018

Convener, International Conference on Drug Discovery: Biotech and Pharma at Crossroads, 15-17th Feb 2018, Thapar Institute of Engineering and Technology, Patiala.

2017

Coordinator, summer training Program in “Advances in Modern Biotechnology”, 05th June 2017-12th July 2017, Thapar Institute of Engineering and Technology, Patiala

2014

Coordinator, Summer Training Program in Modern Biotechnology from 09 June 2014- 15 July 2014, TIFAC- Centre for Relevance and Excellence (CORE) in Agro & Industrial Biotechnology, Thapar University, Patiala.

2007

Organizing Secretary, National Conference on Fungal Diversity: Impact & Exploitation and 34th Annual Meeting of Mycological Society of India, 05-06 October 2007, Thapar University, Thapar Technology Campus, Patiala 147004.

2006

Resource person & Course Coordinator in Short term course on “In vitro antimicrobial susceptibility testing systems: a road to antimicrobial drug discovery” sponsored by TIFAC-CORE in Agro & Industrial Biotechnology, Thapar University (previously Thapar Institute of Engineering & Technology), Patiala; AB Biodisk Sweden from 15-18 Feb. 2006

2002

Course Coordinator, Short-term course in Microbial Technology, Centre of Relevance & Excellence in Agro & Industrial Biotechnology, Thapar University (previously Thapar Institute of Engineering & Technology), Patiala from 28th September –11th October 2002

 

Resource Person, theoretical and practical training in Gas Chromatography in the short-term course on Microbial Technology organized by Centre of Relevance & Excellence in Agro & Industrial Biotechnology, Thapar University (previously Thapar Institute of Engineering & Technology, Patiala from 01-06 March 2002

TEACHING EXPERIENCE (+18 YEARS)

Undergraduate courses Applied Microbiology (BT003) Bioanalytical Techniques (BT005)  Biomanufacturing (UBT014)   Pharmaceutical Biotechnology (UBT014) ● Biosafety, Bioethics and IPR (UBT801)Medical Biotechnology (UBT609)

Postgraduate courses   Biochemistry (PBT103) Bioenergetics and Intermediary Metabolism (PBC201) Industrial Enzyme Technology (PBY 204)Drug Discovery and Design (PBC 401)        Animal Biotechnology (PBC 301) Drug Discovery and Design (PBY 305) Pharmaceutical Microbiology (PBC 301) Microbial Technology (PBT 206)