Dr. Manoj Baranwal

Associate Professor

Specialization

Viral Immunology, Computational Biology

Email

manoj.baranwal@thapar.edu

Specialization

Viral Immunology, Computational Biology

Email

manoj.baranwal@thapar.edu

Linkedin 

Google Scholar

Website Link

Educational Qualification

  1. Ph.D (Immunology): University of Duisburg-Essen, Germany (2007)
  2. PG Diploma (Bioinformatics): Bioinformatics Centre, Jawaharlal Nehru University (JNU), New Delhi (2003)
  3. M.Sc (Life Sciences): School of Life Sciences, JNU, New Delhi (2002)
  4. B.Sc (Chemisty): Gaya College, Magadh University, Gaya (2000)

Professional Experience

  1. • Associate Professor, Dept of Biotechnology, Thapar Institute of engineering and Technology, Patiala (10th July 2017 to till date)
  2. Assistant Professor: Dept of Biotechnology, Thapar Institute of Engineering & Technology, Patiala (July 2009-July 2017)
  3. Assistant Professor: Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Pune (March 2008-July 2009)
  4. Postdoctoral Research Fellow: Institute of Immunology, University Hospital, Essen, Germany (March 2007 to January 2008)

Research Interest 

  • Immunoinformatics and cellular immunology with prime focus in peptide based vaccine design against viral disease
  • Anticancer & immunomodulatory study of natural products and nanoparticles.
  • Development of disease predictive model with application of machine learning and artificial intelligence.

Research Projects

  • In silico and in vitro approach to identify immunogenic peptides of H1N1 virus as a target for vaccine design from DST, New Delhi, Sanction amount: 23.6 Lakhs (Jan 2013 to Jan 2016) (PI)
  • Identification of T cell Epitope in H1N1 influenza virus as target for vaccine design from AICTE, New Delhi, Sanction amount: 11 lakhs (March 2012 to March 2014) (PI)
  • Immunomodulatory agents from endophytic fungi for breast cancer therapy from DBT, New Delhi, Sanction amount: 16.02 lakhs (Nov 2011 to October 2014) (PI)

As Co-Project Investigator

  • Analysis of virus transport through subsurface media from CSIR, New Delhi, Sanction amount: 23.42 lakhs (Dec 2017 to Nov 2020)

Publication of Research Articles

2021 onwards

  • Patwal, T., & Baranwal, M. (2021). Scenedesmus acutus extracellular polysaccharides produced under increased concentration of sulphur and phosphorus exhibited enhanced proliferation of peripheral blood mononuclear cells. 3 Biotech, 11(4), 171. 

  • Sharma, P., Goyal, D., Baranwal, M., & Chudasama, B. (2021). Oxidative Stress Induced Cytotoxicity of Colloidal Copper Nanoparticles on RAW 264.7 Macrophage Cell Line. Journal of Nanoscience and Nanotechnology, 21(10), 5066–5074.

  • Johri, S., Goyal, M., Jain, S., Baranwal, M., Kumar, V., & Upadhyay, R. (2021). A novel machine learning‐based analytical framework for automatic detection of COVID ‐19 using chest X‐ray images. International Journal of Imaging Systems and Technology, ima.22613

  • Martynova, E., Davidyuk, Y., Kabwe, E., Garanina, E. E., Shakirova, V., Pavelkina, V., Uskova, Y., Stott, R. J., Foster, T. L., Markelova, M., Goyal, M., Gupta, A., Bhola, M., Kumar, V., Baranwal, M., Rizvanov, A. A., & Khaiboullina, S. F. (2021). Cytokine, chemokine, and metalloprotease activation in the serum of patients with nephropathia epidemica from the republic of tatarstan and the republic of mordovia, Russia. Pathogens, 10(5), 527

2018-20

  • Martynova, E., Goyal, M., Johri, S., Kumar, V., Khaibullin, T., Rizvanov, A. A., Verma, S., Khaiboullina, S. F., & Baranwal, M. (2020). Serum and cerebrospinal fluid cytokine biomarkers for diagnosis of multiple sclerosis. Mediators of Inflammation, 2020.

  • Jain, Sahil, Khaiboullina, S. F., & Baranwal, M. (2020). Immunological perspective for ebola virus infection and various treatment measures taken to fight the disease. Pathogens, 9(10), 850.

  • Kaushal, N., Gupta, Y., Goyal, M., Khaiboullina, S. F., Baranwal, M., & Verma, S. C. (2020). Mutational frequencies of SARS-CoV-2 genome during the beginning months of the outbreak in USA. Pathogens, 9(7), 1–16. .

  • Sharma, P., Goyal, D., Baranwal, M., & Chudasama, B. (2020). ROS-induced cytotoxicity of colloidal copper nanoparticles in MCF-7 human breast cancer cell line: an in vitro study. Journal of Nanoparticle Research, 22(8), 244.

  • Goyal, M., Khanna, D., Rana, P. S., Khaibullin, T., Martynova, E., Rizvanov, A. A., Khaiboullina, S. F., & Baranwal, M. (2019). Computational intelligence technique for prediction of multiple sclerosis based on serum cytokines. Frontiers in Neurology, 10, 781 (2019)

  • Goyal, M., Baranwal, M., Pandey, S. K., & Reddy, M. S. (2019). Hetero-Polysaccharides Secreted from Dunaliella salina Exhibit Immunomodulatory Activity Against Peripheral Blood Mononuclear Cells and RAW 264.7 Macrophages. Indian Journal of Microbiology, 59 (4), 428-435 .

  • Jain, S., & Baranwal, M. (2019). Conserved peptide vaccine candidates containing multiple Ebola nucleoprotein epitopes display interactions with diverse HLA molecules. Medical Microbiology and Immunology,208: 227-238

  • Jain, S., & Baranwal, M. (2019). Computational analysis in designing T cell epitopes enriched peptides of Ebola glycoprotein exhibiting strong binding interaction with HLA molecules. Journal of Theoretical Biology, 465, 34-44

  • Dhiman, G., Srivastava, N., Goyal, M., Rakha, E., Lothion-Roy, J., Mongan, N. P., Miftakhova, R. R., Khaiboullina, S. F., Rizvanov, A. A., & Baranwal, M. (2019). Metadherin: A therapeutic target in multiple cancers. Frontiers in Oncology 9, 349

  • Goyal, M., Kaur H., Bhandari M., Rizvanov, A. A., Khaiboullina, S. F., & Baranwal, M. (2018) Antioxidant and Immune Effects of Water Soluble Polysaccharides Isolated from Cinnamomum verum Bark. BioNanoScience, 8(3), 935-940

  • Khaiboullina S., Uppal T., Martynova E., Rizvanov A., Baranwal, M. & Verma S. C. (2018) History of ZIKV infections in India and management of disease outbreaks. Frontiers in Microbiology, 9, 2126 

  • Lohia N., & Baranwal, M. (2018) Highly conserved hemagglutinin peptides of the H1N1 influenza virus elicit immune response. 3 Biotech, 8(12), 492

2014-17

  • Lohia, N., & Baranwal, M. (2017). Immune responses to highly conserved influenza A virus matrix 1 peptides. Microbiology and Immunology, 61(6), 225-231.

  • Sharma, V., Lohia, N., Handa, V., & Baranwal, M. (2017). Amomum subulatum seed extract exhibit antioxidant, cytotoxic and immune-suppressive effect. Indian Journal of Biochemistry and Biophysics, 54(3–4)..

  • Vasundhara, M., Baranwal, M., Sivaramaiah, N., & Kumar, A. (2017). Isolation and characterization of trichalasin-producing endophytic fungus from Taxus baccata. Annals of Microbiology, 67(3), 255-261.

  • Dhiman, G., Lohia, N., Jain, S., & Baranwal, M. (2016). Metadherin peptides containing CD4+and CD8+T cell epitopes as a therapeutic vaccine candidate against cancer. Microbiology and Immunology, 60(9), 646-652.

  • Singh, P., Baranwal, M., & Reddy, S. M. (2016). Antioxidant and cytotoxic activity of carotenes produced by Dunaliella salina under stress. Pharmaceutical Biology, 54(10) 2269-2275.

  • Vasundhara, M., Baranwal, M., & Kumar, A. (2016). Fusarium tricinctum, An Endophytic Fungus Exhibits Cell Growth Inhibition and Antioxidant Activity. Indian Journal of Microbiology,  56(4), 433-438.

  • Lohia, N., & Baranwal, M. (2015). Identification of conserved peptides comprising multiple T Cell epitopes of matrix 1 protein in H1N1 influenza virus. Viral Immunology, 28(10), 570-579 (2015).

  • Lohia, N., & Baranwal, M. (2014). Conserved peptides containing overlapping CD4+ and CD8+ T-cell epitopes in the H1N1 influenza virus: An immunoinformatics approach. Viral Immunology, 27(5), 225-234.​

Before 2014

  • Putzki, N., Baranwal, M. K., Tettenborn, B., Limmroth, V., & Kreuzfelder, E. (2010). Effects of natalizumab on circulating B cells, T regulatory cells and natural killer cells. European Neurology,63(5), 311-317 (2010).

  • Putzki, N., Kumar, M., Kreuzfelder, E., Grosse-Wilde, H., Diener, H. C., & Limmroth, V. (2008). Mitoxantrone does not restore the impaired suppressive function of natural regulatory t cells in patients suffering from multiple sclerosis. European Neurology, 61(1) 27-32.

  • Yaldizli, O., Kumar, M., Vago, S., Kreuzfelder, E., Limmroth, V., & Putzki, N. (2009). Fatigue is not associated with impaired function of regulatory T cells in untreated patients with multiple sclerosis. European Neurology, 62(6), 321.

  • Kumar, M., Putzki, N., Limmroth, V., Remus, R., Lindemann, M., Knop, D., Mueller, N., Hardt, C., Kreuzfelder, E., & Grosse-Wilde, H. (2006). CD4+CD25+FoxP3+T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis. Journal of Neuroimmunology, 180(1), 178-184.

Chapters

  • Lohia, N., & Baranwal, M. (2020) An Immunoinformatics Approach in Design of Synthetic Peptide Vaccine Against Influenza Virus. In Immunoinformatics.  Humana, New York, NY, 229-243.

  • Tania, Goyal M., & Baranwal, M. (2018) In Silico Approach to Analyze the Biochemical Pathways of Bacterial Metabolite Synthesis. In:  In Silico Approach for Sustainable Agriculture. Springer, 141-159 

Research Guidance

  • PhD: Completed (2) and Ongoing (5)
  • M.Sc/M.Tech: Completed (25)

Research Collaboration: Kazan Federal University, Russia

Membership of national/International organization

  1. Life Member of Indian Immunological society
  2. Life Member of Mycology society of India
  3. Member of German Society of Immunology from 2005-2007

Courses Taught:

Immunology, Cancer biology and infectious disease, Applied Immunology & Vaccine Technology, Advanced Bioinformatics, Bioinformatics & System Biology, Virology, Animal Biotechnology, Stem Cells, Bioethics, Environmental studies.

Programme Organized

  • 1. National conference on Emerging Trends in Biopharmaceuticals: Relevance to Human Health during, held at Thapar University, Patiala, Punjab (November 11-13th, 2010) as Organizer Secretary.
  • 2. International conference on Drug Discovery: Biotech and Pharma at CrossRoads, being organized by the Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala (15-17th Feb 2018) as Treasurer.