Specialization

Viral Immunology, Computational Biology

Email

manoj.baranwal@thapar.edu; Date of Joining: 31-07-2009

Linkedin 

Google Scholar

Website Link

Educational Qualification

1. Ph.D (Immunology): University of Duisburg-Essen, Germany (2007)
2. PG Diploma (Bioinformatics): Bioinformatics Centre, Jawaharlal Nehru University (JNU), New Delhi (2003)
3. M.Sc (Life Sciences): School of Life Sciences, JNU, New Delhi (2002)
4. B.Sc (Chemisty): Gaya College, Magadh University, Gaya (2000)

Professional Experience

1. Professor, Dept of Biotechnology, Thapar Institute of engineering and Technology (TIET), Patiala (1st July 2022 to till date)

2. Associate Professor, Dept of Biotechnology, Thapar Institute of engineering and Technology, Patiala (10th July 2017 to 30th June 2022)
3. Assistant Professor: Dept of Biotechnology, Thapar Institute of Engineering & Technology, Patiala (July 2009-July 2017)
4. Assistant Professor: Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Pune (March 2008-July 2009)
5. Postdoctoral Research Fellow: Institute of Immunology, University Hospital, Essen, Germany (March 2007 to January 2008)

Research Interest 

• Immunoinformatics and cellular immunology with prime focus in peptide based vaccine design against viral disease
• Anticancer & immunomodulatory study of natural products and nanoparticles.
• Development of disease predictive model with application of machine learning and artificial intelligence.

Research Projects

• Identification of immunogenic peptide for diagnosis of orthohantavirus infection: under Indo-Russian Joint Research Call  from DST, New Delhi: Sanction Amount:87.29 Lakhs (2023-2026) (PI)

• In silico and in vitro approach to identify immunogenic peptides of H1N1 virus as a target for vaccine design from DST, New Delhi, Sanction amount: 23.6 Lakhs (Jan 2013 to Jan 2016) (PI)
• Identification of T cell Epitope in H1N1 influenza virus as target for vaccine design from AICTE, New Delhi, Sanction amount: 11 lakhs (March 2012 to March 2014) (PI)
• Immunomodulatory agents from endophytic fungi for breast cancer therapy from DBT, New Delhi, Sanction amount: 16.02 lakhs (Nov 2011 to October 2014) (PI)

As Co-Project Investigator

• Analysis of virus transport through subsurface media from CSIR, New Delhi, Sanction amount: 23.42 lakhs (Dec 2017 to Nov 2020)

Publication of Research Articles: 

 

2024

[1] L. Shkair, D. Sharma, S. Hamza, E. Garanina, V. Shakirova, I. Khaertynova, M. Markelova, V. Pavelkina, A. Rizvanov, S.B. Khaiboullina, M. Baranwal, E. Martynova, Cross‐reactivity of hantavirus antibodies after immunization with PUUV antigens, Biotechnology and Applied Biochemistry  (2024).

[2] A. Sehgal, D. Sharma, N. Kaushal, Y. Gupta, E. Martynova, E. Kabwe, S. Chandy, A. Rizvanov, S. Khaiboullina, M. Baranwal, Designing a Conserved Immunogenic Peptide Construct from the Nucleocapsid Protein of Puumala orthohantavirus, Viruses 16(7) (2024) 1030.

[3] N. Kaushal, M. Baranwal, Analysis of highly frequent point mutations in glycoprotein C, glycoprotein N, and nucleoprotein of CCHFV, Biotechnology and Applied Biochemistry 71(2) (2024) 280-294.

[4] Y. Gupta, M. Baranwal, B. Chudasama, Zika virus precursor membrane peptides induce immune response in peripheral blood mononuclear cells, Human Immunology 85(2) (2024) 110761.

[5] A. Choudhary, A. Anand, A. Singh, P. Roy, N. Singh, V. Kumar, S. Sharma, M. Baranwal, Machine learning-based ensemble approach in prediction of lung cancer predisposition using XRCC1 gene polymorphism, Journal of Biomolecular Structure and Dynamics 42(15) (2024) 7828-7837.

 

2023

 

[6] J. Verma, N. Kaushal, M. Manish, N. Subbarao, V. Shakirova, E. Martynova, R. Liu, S. Hamza, A.A. Rizvanov, S.F.B. Khaiboullina, Manoj, Identification of conserved immunogenic peptides of SARS-CoV-2 nucleocapsid protein, Journal of Biomolecular Structure and Dynamics  (2023) 1-17.

[7] N. Srivastava, M. Baranwal, B. Chudasama, Evaluation of Magnetic Hyperthermia Efficiency of PEG-Coated Fe3O4 Nanoparticles, Nano 18(12) (2023) 2350094.

[8] S. Singh, N. Singh, M. Baranwal, S. Sharma, S.K. Devi, S. Kumar, Understanding immune checkpoints and PD-1/PD-L1-mediated immune resistance towards tumour immunotherapy, 3 Biotech 13(12) (2023) 411.

[9] S. Singh, N. Singh, M. Baranwal, S. Sharma, Association of MLH1-93G> A polymorphisms toward lung cancer susceptibility and its association with clinical outcome in North Indian patients treated with platinum-based chemotherapy, Journal of Cancer Research and Therapeutics 19(Suppl 1) (2023) S397-S403.

[10] A. Sehgal, S. Mehta, K. Sahay, E. Martynova, A. Rizvanov, M. Baranwal, S. Chandy, S. Khaiboullina, E. Kabwe, Y. Davidyuk, Hemorrhagic fever with renal syndrome in Asia: history, pathogenesis, diagnosis, treatment, and prevention, Viruses 15(2) (2023) 561.

[11] D. Ratha, R. Babbar, K. Hariprasad, C. Ojha, M. Baranwal, P.R. Rout, A. Parihar, Mathematical Transport System of Microconstituents, Microconstituents in the Environment: Occurrence, Fate, Removal and Management  (2023) 107-131.

[12] E. Martynova, T. Khaibullin, I. Salafutdinov, M. Markelova, A. Laikov, L. Lopukhov, R. Liu, K. Sahay, M. Goyal, M.R. Baranwal, Albert, S. Khaiboullina, Seasonal changes in serum metabolites in multiple sclerosis relapse, International Journal of Molecular Sciences 24(4) (2023) 3542.

[13] N. Kaushal, M. Baranwal, Mutational analysis of catalytic site domain of CCHFV L RNA segment, Journal of Molecular Modeling 29(4) (2023) 88.

[14] S. Jain, S. Khaiboullina, E. Martynova, S. Morzunov, M. Baranwal, Epidemiology of ebolaviruses from an etiological perspective, Pathogens 12(2) (2023) 248.

[15] Y. Gupta, M. Baranwal, B. Chudasama, Immunoinformatics-Based Identification of the Conserved Immunogenic Peptides Targeting of Zika Virus Precursor Membrane Protein, Viral Immunology 36(8) (2023) 503-519.

[16] G. Gupta, M. Baranwal, S. Saxena, M.S. Reddy, Utilization of banana waste as a resource material for biofuels and other value-added products, Biomass Conversion and Biorefinery 13(14) (2023) 12717-12736.

[17] A. Chalotra, D. Ratha, R. Babbar, M. Baranwal, A study on transport of Escherichia coli through saturated porous medium, International Journal of Environmental Science and Technology 20(6) (2023) 6761-6776.

[18] A. Chalotra, R. Babbar, D. Ratha, M. Baranwal, P.R. Rout, Assessment of kinetic and statistical models for predicting breakthrough curves of bio-colloid transport through saturated porous media, Journal of Contaminant Hydrology 259 (2023) 104246.

 

2022

[19] N. Srivastava, B. Chudasama, M. Baranwal, Advancement in magnetic hyperthermia-based targeted therapy for cancer treatment, Biointerphases 18(6) (2022).

[20] S. Singh, N. Singh, M. Baranwal, S. Sharma, Structural, functional analysis and association of MSH6 rs1800932, rs1042821 polymorphisms with clinical outcome in North Indian lung cancer patients treated with platinum-based doublet chemotherapy, The American Journal of the Medical Sciences 364(6) (2022) 735-745.

[21] S. Singh, N. Singh, M. Baranwal, S. Sharma, Polymorphisms in the MSH2 gene predict poor survival of North Indian lung cancer patients undergoing chemotherapy, Biomarkers in Medicine 16(2) (2022) 69-82.

[22] M. Singh, S. Mishra, J. Mehta, A. Bansal, M. Baranwal, R. Upadhyay, V. Kumar, Electroencephalogram Data Collection for Student Engagement Analysis with Audio-Visual Content, bioRxiv  (2022) 2022.09. 20.508656.

[23] S. Punj, N. Srivastava, M. Baranwal, K. Singh, In-vitro biological evaluation of diopside bio-ceramic synthesized from sustainable agro-food waste ashes, Silicon  (2022) 1-11.

[24] E. Martynova, S. Hamza, M. Markelova, E. Garanina, Y. Davidyuk, V. Shakirova, N. Kaushal, M. Baranwal, R. Stott-Marshall, T.R. Foster, Albert, S. Khaiboullina, Immunogenic SARS-CoV-2 S and N protein peptide and cytokine combinations as biomarkers for early prediction of fatal COVID-19, Frontiers in Immunology  (2022) 846.

[25] R. Liu, S. Du, L. Zhao, S. Jain, K. Sahay, A. Rizvanov, V. Lezhnyova, T. Khaibullin, E. Martynova, S.B. Khaiboullina, Baranwal M, Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target, Frontiers in Immunology 13 (2022) 996469.

[26] N. Kaushal, S. Jain, M. Baranwal, Computational design of immunogenic peptide constructs comprising multiple human leukocyte antigen restricted dengue virus envelope epitopes, Journal of Molecular Recognition 35(9) (2022) e2961.

[27] G. Gupta, S. Saxena, M. Baranwal, M.S. Reddy, In vitro evaluation of bioactive properties of banana sap, Biologia 77(10) (2022) 2989-3000.

[28] E. Garanina, S. Hamza, R.J. Stott-Marshall, E. Martynova, M. Markelova, Y. Davidyuk, V. Shakirova, N. Kaushal, M. Baranwal, I.M.R. Khaertynova, A.A. Rizvanov, Foster, Toshana, S. Khaiboullina, Antibody and T cell immune responses to SARS-CoV-2 peptides in COVID-19 convalescent patients, Frontiers in Microbiology 13 (2022) 842232.

 

2021

[29] S. Singh, S. Sharma, M. Baranwal, Identification of SNPs in hMSH3/MSH6 interaction domain affecting the structure and function of MSH2 protein, Biotechnology and Applied Biochemistry  (2021).

[30] P. Sharma, D. Goyal, M. Baranwal, B. Chudasama, Oxidative stress induced cytotoxicity of colloidal copper nanoparticles on RAW 264.7 macrophage cell line, Journal of Nanoscience and Nanotechnology 21(10) (2021) 5066-5074.

[31] T. Patwal, M. Baranwal, Scenedesmus acutus extracellular polysaccharides produced under increased concentration of sulphur and phosphorus exhibited enhanced proliferation of peripheral blood mononuclear cells, 3 Biotech 11(4) (2021) 171.

[32] E. Martynova, S. Hamza, E.E. Garanina, E. Kabwe, M. Markelova, V. Shakirova, I.M. Khaertynova, N. Kaushal, M. Baranwal, A.A.R.A.U.K. Rizvanov, Svetlana, Long term immune response produced by the SputnikV vaccine, International Journal of Molecular Sciences 22(20) (2021) 11211.

[33] E. Martynova, Y. Davidyuk, E. Kabwe, E.E. Garanina, V. Shakirova, V. Pavelkina, Y. Uskova, R.J. Stott, T.L. Foster, M.G. Markelova, M.Goyal, A. Gupta,  M. Bhola, V. Kumar, M. Baranwal, A. Rizvanov, S. Khaiboullina, Cytokine, chemokine, and metalloprotease activation in the serum of patients with nephropathia epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia, Pathogens 10(5) (2021) 527.

[34] S. Johri, M. Goyal, S. Jain, M. Baranwal, V. Kumar, R. Upadhyay, A novel machine learning‐based analytical framework for automatic detection of COVID‐19 using chest X‐ray images, International Journal of Imaging Systems and Technology 31(3) (2021) 1105-1119.

[35] S. Jain, E. Martynova, A. Rizvanov, S. Khaiboullina, M. Baranwal, Structural and functional aspects of Ebola virus proteins, Pathogens 10(10) (2021) 1330.

[36] S. Jain, M. Baranwal, Conserved immunogenic peptides of Ebola glycoprotein elicit immune response in human peripheral blood mononuclear cells, Microbiology and Immunology 65(11) (2021) 505-511.

[37] S. Jain, M. Baranwal, Immunoinformatics aided design of peptide-based vaccines against ebolaviruses, Vitamins and Hormones, Academic Press2021, pp. 157-187.

[38] M. Baranwal, Y. Gupta, P. Dey, S. Majaw, Antiinflammatory phytochemicals against virus‐induced hyperinflammatory responses: Scope, rationale, application, and limitations, Phytotherapy Research  (2021).

 

2018-2020

[39] P. Sharma, D. Goyal, M. Baranwal, B. Chudasama, ROS-induced cytotoxicity of colloidal copper nanoparticles in MCF-7 human breast cancer cell line: an in vitro study, Journal of Nanoparticle Research 22 (2020) 1-11.

[40] E. Martynova, M. Goyal, S. Johri, V. Kumar, T. Khaibullin, A.A. Rizvanov, S. Verma, S.F. Khaiboullina, M. Baranwal, Serum and cerebrospinal fluid cytokine biomarkers for diagnosis of multiple sclerosis, Mediators of inflammation 2020(1) (2020) 2727042.

[41] N. Lohia, M. Baranwal, An immunoinformatics approach in design of synthetic peptide vaccine against influenza virus, Immunoinformatics  (2020) 229-243.

[42] N. Kaushal, Y. Gupta, M. Goyal, S.F. Khaiboullina, M. Baranwal, S.C. Verma, Mutational frequencies of SARS-CoV-2 genome during the beginning months of the outbreak in USA, Pathogens 9(7) (2020) 565.

[43] S. Jain, S.F. Khaiboullina, M. Baranwal, Immunological perspective for Ebola virus infection and various treatment measures taken to fight the disease, Pathogens 9(10) (2020) 850.

[44] S. Jain, M. Baranwal, Computational analysis in designing T cell epitopes enriched peptides of Ebola glycoprotein exhibiting strong binding interaction with HLA molecules, Journal of Theoretical Biology 465 (2019) 34-44.

[45] S. Jain, M. Baranwal, Conserved peptide vaccine candidates containing multiple Ebola nucleoprotein epitopes display interactions with diverse HLA molecules, Medical Microbiology and Immunology 208 (2019) 227-238.

[46] G. Gupta, M. Baranwal, S. Saxena, M.S. Reddy, Utilization of banana stem juice as a feedstock material for bioethanol production, CLEAN–Soil, Air, Water 47(9) (2019) 1900047.

[47] M. Goyal, D. Khanna, P.S. Rana, T. Khaibullin, E. Martynova, A.A. Rizvanov, S.F. Khaiboullina, M. Baranwal, Computational intelligence technique for prediction of multiple sclerosis based on serum cytokines, Frontiers in neurology 10 (2019) 781.

[48] M. Goyal, M. Baranwal, S.K. Pandey, M.S. Reddy, Hetero-polysaccharides secreted from Dunaliella salina exhibit immunomodulatory activity against peripheral blood mononuclear cells and RAW 264.7 macrophages, Indian journal of microbiology 59 (2019) 428-435.

[49] G. Dhiman, N. Srivastava, M. Goyal, E. Rakha, J. Lothion-Roy, N.P. Mongan, R.R. Miftakhova, S.F. Khaiboullina, A.A. Rizvanov, M. Baranwal, Metadherin: a therapeutic target in multiple cancers, Frontiers in oncology 9 (2019) 349.

[50] Tania, M. Goyal, M. Baranwal, In Silico Approach to Analyze the Biochemical Pathways of Bacterial Metabolite Synthesis, In Silico Approach for Sustainable Agriculture  (2018) 141-159.

[51] N. Lohia, M. Baranwal, Highly conserved hemagglutinin peptides of H1N1 influenza virus elicit immune response, 3 Biotech 8 (2018) 1-10.

[52] S. Khaiboullina, T. Uppal, E. Martynova, A. Rizvanov, M. Baranwal, S.C. Verma, History of ZIKV infections in India and management of disease outbreaks, Frontiers in Microbiology 9 (2018) 2126.

[53] M. Goyal, H. Kaur, M. Bhandari, A.A. Rizvanov, S.F. Khaiboullina, M. Baranwal, Antioxidant and immune effects of water soluble polysaccharides isolated from Cinnamomum verum bark, BioNanoScience 8 (2018) 935-940.

 

2014-2017

[54] M. Vasundhara, M. Baranwal, N. Sivaramaiah, A. Kumar, Isolation and characterization of trichalasin-producing endophytic fungus from Taxus baccata, Annals of Microbiology 67 (2017) 255-261.

[55] V. Sharma, N. Lohia, V. Handa, M. Baranwal, Amomum subulatum seed extract exhibit antioxidant, cytotoxic and immune-suppressive effect, Indian J Biochem Biophys 54 (2017) 135-139.

[56] N. Lohia, M. Baranwal, Immune responses to highly conserved influenza A virus matrix 1 peptides, Microbiology and immunology 61(6) (2017) 225-231.

[57] M. Vasundhara, M. Baranwal, A. Kumar, Fusarium tricinctum, an endophytic fungus exhibits cell growth inhibition and antioxidant activity, Indian journal of microbiology 56 (2016) 433-438.

[58] P. Singh, M. Baranwal, S.M. Reddy, Antioxidant and cytotoxic activity of carotenes produced by Dunaliella salina under stress, Pharmaceutical biology 54(10) (2016) 2269-2275.

[59] G. Dhiman, N. Lohia, S. Jain, M. Baranwal, Metadherin peptides containing CD4+ and CD8+ T cell epitopes as a therapeutic vaccine candidate against cancer, Microbiology and immunology 60(9) (2016) 646-652.

[60] N. Lohia, M. Baranwal, Identification of conserved peptides comprising multiple T cell epitopes of matrix 1 protein in H1N1 influenza virus, Viral immunology 28(10) (2015) 570-579.

[61] N. Lohia, M. Baranwal, Conserved peptides containing overlapping CD4+ and CD8+ T-cell epitopes in the H1N1 influenza virus: an immunoinformatics approach, Viral Immunology 27(5) (2014) 225-234.

 

Before 2014

 

[62] N. Putzki, M.K. Baranwal, B. Tettenborn, V. Limmroth, E. Kreuzfelder, Effects of natalizumab on circulating B cells, T regulatory cells and natural killer cells, European Neurology 63(5) (2010) 311-317.

 

[63] Ö. Yaldizli, M. Kumar, S. Vago, E. Kreuzfelder, V. Limmroth, N. Putzki, Fatigue is not associated with impaired function of regulatory T cells in untreated patients with multiple sclerosis, European neurology 62(6) (2009) 321-326.

[64] N. Putzki, M. Kumar, E. Kreuzfelder, H. Grosse-Wilde, H. Diener, V. Limmroth, Mitoxantrone Does Not Restore the Impaired Suppressive Function of Natural Regulatory T Cells in Patients Suffering from Multiple SclerosisA Longitudinal ex vivo and in vitro Study, European neurology 61(1) (2008) 27-32.

[65] M. Kumar, N. Putzki, V. Limmroth, R. Remus, M. Lindemann, D. Knop, N. Mueller, C. Hardt, E. Kreuzfelder, H. Grosse-Wilde, CD4+ CD25+ FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis, Journal of Neuroimmunology 180(1-2) (2006) 178-184

 

Research Guidance

• PhD: Completed (5) and Ongoing (7)
• M.Sc/M.Tech: Completed (41)

Research Collaboration:

International: Kazan Federal University, Russia, Tel Aviv University, Israel

National: Childs Trust Medical Research Foundation (CTMRF) Kanchi, Chennai, India, The Institute of Microbial Technology, Chandigarh

Membership of national/International organization

1. Life Member of Indian Immunological society
2. Life Member of Mycology society of India
3. Member of German Society of Immunology from 2005-2007

Courses Taught:

Immunotechnology, Clinical Immunology, Applied Immunology & Vaccine Technology,Cancer biology and infectious disease, Advanced Bioinformatics, Bioinformatics & System Biology, Virology, Animal Biotechnology, Stem Cells, Bioethics, Environmental studies.

Programme Organized

• 1. National conference on Emerging Trends in Biopharmaceuticals: Relevance to Human Health during, held at Thapar University, Patiala, Punjab (November 11-13th, 2010) as Organizer Secretary.
• 2. International conference on Drug Discovery: Biotech and Pharma at CrossRoads, being organized by the Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala (15-17th Feb 2018) as Treasurer.

Academic Activity

Current Activity

•Chairman of Institutional ethical committee

•UG Coordinator

Past Activity

•Department NBA coordinator

•Department Time Table coordinator

•Department Faculty placement coordinator

•UG coordinator of B. Tech Biotechnology

•Industry associated project coordinator

•Deputy superintendent (End semester examination conduct)

•Member of several admission committee